This book contains comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters such as P-glycoprotein, multidrug resistance-associated proteins, and breast cancer resistance protein to the drug ratio-dependent antagonism and the paradigm of cancer stem cells. In addition, the development of agents or strategies to overcome resistance has been the subject of intense study. In the past three decades, a number of mechanisms by which cancer cells acquire multidrug resistance have been discovered. Printed on acid-free paper Springer is part of Springer Science+Business Media (Preface Chemotherapy is one of the major treatment options for cancer patients however, the efficacy of chemotherapeutic management of cancer is severely limited by multidrug resistance, in that cancer cells become simultaneously resistant to many structurally and mechanistically unrelated drugs.
The publisher makes no warranty, express or implied, with respect to the material contained herein. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Jun Zhou Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, Tianjin, ChinaĮditor Jun Zhou Department of Genetics and Cell Biology College of Life Sciences Nankai University Tianjin China Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UKįor other titles published in this series, go to Multi-Drug Resistance in Cancer Edited by
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